Blue tongues from taking blue cannatine
Myself and Alex Fergus Showing Our Blue Tongues from Taking Blue Cannatine
Reviewed by the BioHackers Lab Team | Last updated: February 5, 2023

Are you are interested in boosting your mitochondria for more energy, or wondering why you are seeing people share Instagram pictures of their blue tongues?

Then you will want to a look into trying out Blue Cannatine from Troscriptions.

The tl;dr is – I can recommend Blue Cannatine as a good thing to try at least once to see how you feel. I trust Dr Ted and Dr Sherr and what they are up to.

Use the Blue Cannatine coupon code – biohackerslab – at the Troscription website here to get a nice 10% discount on your purchase.

What is Blue Cannatine?

Blue Cannatine is a buccal nootropic supplement developed by medical doctors, Dr Ted Achacoso and Dr Scott Sherr.

Blue Cannatine is designed to help you address some cognitive and physical manifestations of the hypothesised Clinical Endocannabinoid Deficiency (CED) symptoms.

Single blue cannatine troche in the palm of a hand
Single Blue Cannatine Troche in the palm of my hand

Who Should Take Blue Cannatine?

People who should consider taking Blue Cannatine are those interested in nootropic and brain supplements that benefit your mitochondria.

Some examples of people I think who would benefit from trying Blue Cannatine would be:

  • Office workers wanting more energy in a stressful environment
  • Writers wanting to focus on a creative task
  • Mitochondriacs who want to take a supplement to support their mitochondria energy levels
  • Biohackers who want to experiment with methylene blue and nicotine
  • Regular nootropic users looking for a new neuroprotective supplement to try
  • People who feel they have a symptom related to Clinical Endocannabinoid Deficiency like brain fog.

What Will You Feel Taking Blue Cannatine?

When you take Blue Cannatine you should feel a subtle lift in your cognitive energy levels without feeling too much energy too quickly.

Due to this subtle effect there should not be a crash in energy levels, or feeling of tiredness after the active ingredients have worn off.

I personally feel more awake with no jittery or anxiety feeling. If I have woken up feeling groggy and needing a coffee to help wake me up then I would say even a quarter of a Blue Cannatine troche gave me the alertness a coffee would give me, but in a calmer way.


Ingredients listed on blue cannatine box
Ingredients listed on the back of a box of Blue Cannatine

Per serving size of 1 blue cannatine troche:

Active Ingredients

  • Methylene Blue – 5 mg
  • Nicotine Polacrilex – 1 mg
  • Caffeine – 50 mg
  • Hemp Extract – 5 mg

Other Ingredients

Polyethelyne glycol, stevia extract, lou han extract, peppermint, silica, Bitter-Bloc™


The recommended Blue Cannatine dosage to start with is ¼-½ of a single troche. You can then increase to taking a full troche. 1 troche should be taken every 3 to 4 hours if needed.

The maximum amount of blue cannatine troche’s you can take in a 24 hour period is four.

Half-Life of Methylene Blue

You need to be aware that methylene blue has a half life of 4-6 hours when taken by buccal administration as a troche.

Here is an example of how long it would take for 1 troche that contains 16 mg of methylene blue to be broken down and leave your general circulation. This calculation is assuming you took 1 whole troche at 8am.

TimeDose Remaining
8am16 mg
2pm8 mg
8pm4 mg
2am2 mg
8am1 mg

The reason you want to know this is because if you take the supplement on a regular basis there can be a buildup of methylene blue in your system that you need to be careful of not to eventually develop possible toxicity.

Benefits of Blue Cannatine

The main benefit of all the ingredients in Troscriptions Blue Cannatine are that they compliment each other to help give you a feeling of productivity, focus, verbal fluidity and more for 3 to 5 hours.

1. Methylene Blue Benefits

The benefits of Methylene Blue are:

2. Nicotine Benefits

The cognitive benefits of nicotine are:

3. Hemp Extract Benefits

The benefits of hemp extract is that it contains cannabidiol, which interacts with the endocannabinoid system (ECS).

The endocannabinoid system (ECS) has a lot of positive benefits in our bodies that is still being researched. Our interview with Dr Philip Blair went into a lot more detail on the benefits of cannabinoids.

4. Caffeine Benefits

The cognitive benefits of caffeine are:

  • Improved attention and alertness
  • Improved reaction speed and accuracy
  • Improved coordination and judgement
  • Improved strength and endurance
  • Improved memory


The two most common side-effects I noticed from taking Blue Cannatine were:

  1. My tounge and gums temporarily turned blue where the troche dissolved in my mouth.
  2. My urine color temporarily turned a blueish-green color. This is also due to the methylene blue and is temporary and normal.

If you have never ingested any of the active ingredients before then these might be some things to be aware of before taking them.

  • Caffeine sensitivity
  • Nicotine sensitivity
  • Methylene blue drug interactions – If you are taking a SSRI or MAOI medication, or ingesting a plant that my have this same effect it is then recommended not to take Blue Cannatine for risk of serotonin syndrome. I recommend you read the FDA drug safety note on this warning.

The risk of experiencing any moderate to severe side effect from taking Blue Cannatine is probably very low, however, check the troscription website for further details and consult your physician.

I personally do not have a sensitivity to these ingredients and so felt good when taking a troche.


Always consult your doctor before trying new supplements, but especially if you are take antidepressant medication then DO NOT take methylene blue containing supplements like Blue Cannatine. Selective serotonin reuptake inhibitors (SSRIs), Serotonin and norepinephrine reuptake inhibitors (SNRIs) and psychodelics can cause serotonin syndrome if taken with methylene blue.

How to Take Blue Cannatine

Step 1 – Choose the Dose

Start by deciding how much of the blue cannatine troche you want to take. Beginners are recommended ¼ – ½ of a troche.

Step 2 – Apply in the Correct Postion

Insert the troche dosage you have chosen between your gum and cheek. It doesn’t matter if you choose the left or right side or the upper or lower gum. Most people will do the buccal application between the upper cheek and gum.

Step 3 – Leave the Troche Alone

You might be tempted to help the troche dissolve faster, but you do not need to do that. It is recommended to minimise the movement of the troche and let it naturally dissolve at its own pace The founders like to call this going #SubtleSmurf.

Step 4 – Experience the Feeling

You don’t need to anything else now except just experience the feeling that comes with taking blue cannatine. If you want a faster, stronger effect to be felt then moving the troche to make it dissolve faster will get you that experience, which the Troscription founders like to call going #FullSmurf.

How to Open a Box of Blue Cannatine

Some people have found it a struggle to know how to open the packaging Blue Cannatine comes in.

Watch the video demonstration from Dr Ted to learn how to easily open the box.

I will say that the hard plastic container the four troche come in will is not the easiest to get them out of and make them pop out of their individual slots when pushing from underneath.

I can see some packaging improvements being made over time to also hopefully not have to use a plastic container or maybe some other BPA free solution.

Where to Buy Blue Cannatine?

You can only purchase Blue Cannatine directly from the Troscriptions online store.

Blue click for current price button
Use the Blue Cannatine coupon code – biohackerslab – at the Troscription website here to get a nice 10% discount on your purchase.

Final Thoughts

I think Blue Cannatine is a novel nootropic product that is convenient to take and you can feel the cognitive benefit quickly so this is not a long-term supplement you hope to see some results from, you will know quickly how it makes you feel.

It is worth trying some if you have no contraindications.

My Troscription Blue Cannatine Review (Why I Like It)

Interested in Trying Blue Cannatine? You should be as this new nootropic supplement has some interesting ingredients to help support your mitochondria energy production

Product Brand: Troscriptions

Editor's Rating:


  • Makes you feel good
  • No hyper energy feeling


  • Can make your teeth and tounge look blue for a short period
  • Taking a full troche a day will get expensive