Review of The Best Nicotinamide Riboside Supplements in 2019

White plate with vitamin capsules
What is the Best Nicotinamide Riboside to Buy?

I was interested to find out what are some of the best nicotinamide riboside supplements for me to review.

Taking a good nicotinamide supplement is thought to help NAD+ energy production in our mitochondria.

So I went out researching online for what are some of the highest rated & most recommended nicotinamide supplement products and brands availble to buy online.

Top Rated Nicotinamide Riboside Supplements

Here is a list of recommended NAD+ supplements for you to compare.

1. Tru Niagen Nicotinamide Riboside

  • Capsule Type: vegetarian
  • Dose: 250 mg
  • Capsule count: 60

Tru Niagen’s product is backed by ChromaDex, a pharmaceutical patent company, and is based on the discovery of nicotinamide riboside by Dr. Charles Brenner in 2004. They first released their supplement in 2013 after extensive research, tests and clinical trials. They are located in Irvine, California, and their website offers some educational insight on the science behind why nicotinamide riboside is important for human function. (ref)

Let’s compare some of the other features:

  • Vegetarian capsules are lightweight and easy to swallow
  • Available in five quantity options
  • Has been evaluated by the FDA and given NDI and GRAS ratings
  • Only has to be taken once per day
  • Website is full of useful resources, and the about section details every member of their leadership, creating a sense of familiarity and trust
  • Nicotinamide riboside is their only product, which means all of their focus is dedicated to it
  • Heavy marketing comes off as profit-driven rather than health-focused
  • Tru Niagen is a relatively new company, established in 2013

2. Life Extension NAD+ Cell Regenerator Nicotinamide Riboside

  • Capsule Type: vegetarian
  • Dose: 100 mg
  • Capsule count: 30 (2-pack)

Life Extension has a massive inventory of herbs, supplements and skincare products. They have been around for over 35 years and make over 350 different vitamins and supplements. One of the coolest features of their website is a “Supplement Finder,” where users can input some personal information and find out which supplements are right for them. Life Extension also has an educational magazine and offers lab testing services. (ref)

Let’s compare some of the other features:

  • Life Extension is a well-established company with hundreds of supplements available, as well as a lab testing service and magazine
  • According to self-implemented customer surveys, 98% of customers recommend their products to friends and family
  • Their website is extensive, featuring health education pages, a news section, and a supplement guide
  • In contrast to Tru Niagen, Life Extension’s marketing is so minimal that it’s difficult to figure out what the product does
  • Because Life Extension has so many different products and resources, they are not solely focused on their nicotinamide riboside supplement
  • Their supplement has the lowest dosage

3. Genex Nicotinamide Riboside

  • Capsule Type: vegetarian
  • Dose: 300 mg
  • Capsule count: 60

Genex Formulas is focused on anti-aging supplements. They feature three main products: nicotinamide riboside, nicotinamide mononucleotide and resveratrol, and some of their products are third-party certified. While their website is missing an “About Us” section, they do have a helpful page that explains the science behind NAD+ and its role in the body, as well as how nicotinamide riboside impacts NAD+ levels. (ref)

Let’s compare some of the other features:

  • Supplement bottle and website are very informative as to the benefits of nicotinamide riboside
  • The company only sells three main supplements, so they are focused on those few items
  • High dosage compared to competitors—may be a slightly better value
  • Since Genex does not have an “About Us” section on their website, it is difficult to find out more about the company
  • Heavy marketing combined with the lack of company information might make consumers a little apprehensive
  • Dosage is high enough that side effects may occur

4. Thorne Research ResveraCel Nicotinamide Riboside

  • Capsule Type: vegetarian
  • Dose: 300 mg
  • Capsule count: 60

Thorne’s website is so big that it is almost difficult to navigate through everything they offer. From products to news to wellness guides and more, this research company has a lot to offer even before you purchase their product. They also offer lab testing and a health professional locator. For their nicotinamide riboside, they recently changed their bottle label and the supplement is currently available for purchase with either the new or the old label. (ref)

Let’s compare some of the other features:

  • Contains not only nicotinamide riboside, but also resveratrol and other supplements
  • Thorne claims that all of its ingredients are naturally derived
  • Free of gluten, metallic colorants, eggs, dairy, stearates, BPA, artificial preservatives, high fructose corn syrup, nuts and banned substances
  • Their website is so comprehensive that the resources available are useful for almost anyone, including athletes, health professionals and any health-focused people
  • Although their website is huge, it was difficult to find anything about the history of the company
  • Dosage is high enough that side effects may occur

5. HPN Nutraceuticals Nicotinamide Riboside Metabolic Repair

  • Capsule Type: vegetarian
  • Dose: 250 mg
  • Capsule count: 60

HPN Nutraceuticals sells a handful of different supplements, including resveratrol, omega-3 and glucoside in addition to nicotinamide riboside. Their website makes it easy for consumers, offering separate links for first time customers and returning customers so users know where to start. They have a “Literature” section, which is full of news articles on actual research and studies being done in the supplement world. (ref)

Let’s compare some of the other features:

  • Tested and proven in more than five clinical trials
  • Manufacturing facility is located in the US and is NSF CGMP certified
  • Products are independently tested
  • Their website is very informative and user-friendly
  • They offer a special discount for first-time customers
  • Their product is backed by medical professionals with decades of experience
  • With only a handful of products, they are focused on those few items
  • It was difficult to find anything about the history of the company

Frequently Asked Questions

I know you were looking for what are the best options, but here is some more detail as to why we might need nicotinamide riboside products to help us make more NAD+.

What is Nicotinamide Riboside

Nicotinamide riboside (NR) is a form for vitamin B3 that has been shown to increase levels of nicotinamide adenine dinucleotide (a.k.a NAD+).

Nicotinamide riboside is not the same as the other forms of vitamin B3, nicotinic acid (niacin) & nicotinamide.

Here are each of the forms in which vitamin B3 is found:

  • Nicotinic acid
  • Nicotinamide
  • Nicotinamide riboside

Nicotinamide Riboside Dosages

The suggested dose for nicotinamide riboside is anywhere from 1 to 200 mg per day. Higher doses have shown minimal adverse effects, but any side-effects may be more prominent at higher doses. Users may notice greater differences in energy with higher doses. (ref)

What are the Benefits of Using Nicotinamide Riboside

The potential beneficial functions of nicotinamide riboside are as follows:

  • Improves muscle function
  • Fights cancer and brain diseases like Alzheimer’s
  • Protects the brain, liver and mitochondria
  • Decreases symptoms of diabetes
  • Helps to prevent hearing loss
  • Increases metabolism
  • Helps with weight loss
  • Extends lifespan
  • Regulates the circadian rhythm, or sleep cycle

The benefits of supplementing with nicotinamide riboside appear to be numerous. Although some tests have been done, more knowledge is needed to confirm its uses. (ref)

Pre-clinical trials have shown NAD+ to have anti-aging properties and it helps to generate energy in tissues such as muscle, liver and brain.

Supplementing with a capsule makes it easier to get a more effective dose.

How Does Nicotinamide Riboside Work

Nicotinamide riboside is one of NAD+ precursors and helps to bypass the enzyme called NAMPT which is a rate limiting enzyme for creating NAD+. (ref)(ref)

NAD+ is in every living cell in the human body and plays a role in metabolism, DNA repair and cell signalling.

What is the Science Behind Nicotinamide Riboside

The reason nicotinamide riboside is so beneficial is that it is converted into NAD+ in the body. NAD+ is important for energy, mitochondria and the sleep cycle. (ref)

It also activates the following:

  • Sirtuins, which are anti-aging enzymes
  • PARPs, which are involved in DNA repair
  • CD38, which plays a role in insulin production

What are the Natural Food Sources of Nicotinamide Riboside

Nicotinamide riboside is found in:

  • Cow’s milk
  • Whey protein
  • Brewer’s yeast

Is Nicotinamide Riboside Safe

Nicotinamide riboside is a naturally occurring form of vitamin B3 and is considered very safe. Even at exceptionally high doses, there is no risk of death. The only precaution is for athletes, as higher doses may negatively affect exercise performance.

Basically, all dosages are considered safe, although most nicotinamide riboside supplements have not been approved by the FDA and should be taken with caution and only after consulting with a physician.

Possible Side-Effects

There is no human evidence to show any side effects from taking nicotinamide riboside; however, in animal tests, there may be a decrease in physical performance.

If this applies to humans as well, which we don’t currently know, it is only relevant for athletes or people concerned with athletic performance. Even at high doses up to 5000 mg, there is no risk of overdose or death and only minimal adverse effects have been seen once the dose is increased to 300 mg or higher. (ref)

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Last updated: November 13, 2019

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