What Are The Best Nicotinamide Riboside Supplements?

The best nicotinamide riboside (NR) supplement brands are:

Taking a good NR supplement is thought to help boost NAD+ energy production in our mitochondria and acts as a precursor.

I was interested to find out what are some of the best nicotinamide riboside supplements for me to review.

So, I went out researching online for what are some of the highest rated & most recommended nicotinamide supplement products and brands available to buy online.

The Best Nicotinamide Riboside Supplements in 2024

Here is a list of recommended NR supplements on the market we reviewed for you to compare.

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1. Tru Niagen Nicotinamide Riboside

Tru Niagen uses NIAGEN, the patented NR product owned by ChromaDex,. Dr. Charles Brenner PhD. who discovered nicotinamide riboside can help raise NAD levels in 2004, is on the scientific advisory board. The Tru Niagen website offers a lot of educational insight on the science behind why nicotinamide riboside is important for cellular function. (ref)

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2. Renue By Science Lipo NR Capsules

Renue By Science are a leading supplement brand in making various anti-aging supplements including a nicotinamide riboside supplement. The Renue By Science NR supplement uses liposomal NR as a unique feature vs the other brands we reviewed. There are also no other ingredients alongside the NR. You will find a certificate of analysis on their product page showing the results from the latest ingredient testing.

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3. Thorne NiaCel 400 Nicotinamide Riboside

The Thorne NiaCel 400 formulation is a good option for someone wanting a NR supplement that combines both NR and betaine anhydrous to possibly help enhance their NAD levels. This product contains 85 mg of betaine anhydrous. (ref)

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4. Thorne ResveraCel Nicotinamide Riboside

The Thorne ResveraCel formulation is another good option for someone wanting one supplement that combines both NR and flavonoids, like Quercetin Phytosome, to possibly help enhance sirtuin activity. This product contains 50 mg more resveratrol and 235 mg more quercetin per serving than the Life Extension option. Thorne use nicotinamide riboside hydrogen malate in their ingredient list. (ref)

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5. Life Extension NAD+ Cell Regenerator Nicotinamide Riboside

Life Extension uses NIAGEN® nicotinamide riboside in its NAD+ Cell Regenerator supplement formulation. There are two options with one containing 100 mg and the other 300 mg of NR per capsule. Life Extension is a good option as they are a brand I trust to provide the best dosages and trust their ingredients are what they state on the label. The company has been around for over 35 years and make over 350 different vitamins and supplements. (ref)

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6. Life Extension Optimized NAD+ Cell Regenerator and Resveratrol Elite

The Life Extension Optimized NAD+ Cell Regenerator and Resveratrol formulation also uses NIAGEN® nicotinamide riboside. It contains the bioflavonoid, quercetin, which can help improve the absorption of resveratrol. This Life Extension supplement is a good option for those who want the benefits of taking resveratrol and NR all in one capsule.

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7. Elysium Health Basis NR Supplement

Elysium Health Basis supplement is contains a patent pending form of NR called crystalline nicotinamide riboside (NR-E). The product also contains 50mg of Pterostilbene which is said to work together with the NR to help boost NAD+ levels. The product is NSF Certified for Sport and they link to their ingredient quality lots testing results. Their products was also shown in an RCT study to increase NAD+ levels.

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8. Designs for Health Mito-NR

Designs for Health is a brand that makes a unique version of NR supplement by adding CoQ10 and geranylgeraniol (GG) to their formulation which uses the Niagen form of NR. Adding GG acts as a building block in making CoQ10 and also add CoQ10 which helps mitochondrial energy. So, you can stack NR, CoQ10 and GG in one capsule.

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9. UltraHealth Liposomal Nicotinamide Riboside

UltraHealth is a brand whose NR supplement use a patented form of NR called Ribgen® which is nicotinamide ribisode chloride. They say that their proprietary enteric capsules help the NR get absorb in the small intestine for best bioavailability. We were able to see a certificate of analysis on their product page.

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10. Cytoplan Nicotinamide Riboside

Cytoplan is brand that is only available in the UK. Their NR supplement contains 100 mg of nicotinamide riboside. You may need to order this through an approved Cytoplan practitioner.

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Buyers Guide on Nicotinamide Riboside Supplements

I know you were looking for what are the best options, but here is some more detail as to why we might need nicotinamide riboside products to help us make more NAD+.

What is Nicotinamide Riboside?

Nicotinamide riboside (NR) is a form for vitamin B3 that has been shown to increase levels of nicotinamide adenine dinucleotide (a.k.a NAD+).

Nicotinamide riboside is not the same as the other forms of vitamin B3, nicotinic acid (niacin) & nicotinamide.

Here are each of the forms in which vitamin B3 is found:

• Nicotinic acid
• Nicotinamide
• Nicotinamide riboside

Recommended Dosages

The suggested dose for nicotinamide riboside is anywhere from 1 to 200 mg per day. Higher doses have shown minimal adverse effects, but any side effects may be more prominent at higher doses. Users may notice greater differences in energy with higher doses. (ref)

What Are the Benefits of Using Nicotinamide Riboside?

The potential beneficial functions of nicotinamide riboside are as follows:

• Improves muscle function
• Fights cancer and brain diseases like Alzheimer’s
• Protects the brain, liver and mitochondria
• Decreases symptoms of diabetes
• Helps to prevent hearing loss
• Increases metabolism
• Helps with weight loss
• Extends lifespan
• Regulates the circadian rhythm, or sleep cycle

The benefits of supplementing with nicotinamide riboside appear to be numerous. Although some tests have been done, more knowledge is needed to confirm its uses. (ref)

Preclinical trials have shown NAD+ to have anti-aging properties and it helps to generate energy in tissues such as muscle, liver and brain.

Supplementing with a capsule makes it easier to get a more effective dose.

How Does Nicotinamide Riboside Work?

Nicotinamide riboside is one of NAD+ precursors and helps to bypass the enzyme called NAMPT which is a rate limiting enzyme for creating NAD+. (ref)(ref)

NAD+ is in every living cell in the human body and plays a role in metabolism, DNA repair and cell signalling.

What Is the Science Behind Nicotinamide Riboside?

The reason nicotinamide riboside is so beneficial is that it is converted into NAD+ in the body. NAD+ is important for energy, mitochondria and the sleep cycle. (ref)

It also activates the following:

• Sirtuins, which are anti-aging enzymes
• PARPs, which are involved in DNA repair
• CD38, which plays a role in insulin production

What Are the Natural Food Sources of Nicotinamide Riboside?

Nicotinamide riboside is found in:

• Cow’s milk ^{1, 2}
• Brewer’s yeast ³

Is Nicotinamide Riboside Safe?

Nicotinamide riboside is a naturally occurring form of vitamin B3 and is considered very safe. Even at exceptionally high doses, there is no risk of death. The only precaution is for athletes, as higher doses may negatively affect exercise performance.

Basically, all dosages are considered safe, although most nicotinamide riboside supplements have not been approved by the FDA and should be taken with caution and only after consulting with a physician.

Possible Side Effects

There is no human evidence to show any side effects from taking nicotinamide riboside; however, in animal tests, there may be a decrease in physical performance.

If this applies to humans as well, which we don’t currently know, it is only relevant for athletes or people concerned with athletic performance. Even at high doses up to 5000 mg, there is no risk of overdose or death and only minimal adverse effects have been seen once the dose is increased to 300 mg or higher. (ref)

NR Supplement Frequently Asked Questions

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